Spravato vs. Traditional Antidepressants: What Patients in Tempe Should Know

For patients in Arizona, understanding the differences between these treatments can help guide informed decisions about care. At Phoenix Pointe Psychiatry in Tempe, Arizona, we specialize in both traditional and advanced mental health treatments, including Spravato, therapy, and counseling.

Defining the Terms

Spravato® (Esketamine):
Spravato is an FDA-approved nasal spray for treatment-resistant depression and depressive symptoms in adults with major depressive disorder accompanied by suicidal thoughts or actions. It’s derived from ketamine, a medication long used in anesthesia, and works differently than traditional antidepressants—often providing faster symptom relief.

Traditional Antidepressants:
This category includes medications such as SSRIs (Selective Serotonin Reuptake Inhibitors), SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors), tricyclic antidepressants, and MAOIs (Monoamine Oxidase Inhibitors). These medications generally work by altering brain neurotransmitter levels, and improvements are often noticed after several weeks.

How They Work

• Spravato: Targets the NMDA receptor, influencing glutamate levels—a neurotransmitter involved in mood regulation. This pathway is different from the serotonin- and norepinephrine-based mechanisms of most antidepressants, which is why Spravato can work when others don’t.

• Traditional Antidepressants: Focus on serotonin, norepinephrine, and sometimes dopamine. They require consistent daily use and typically take 4–6 weeks to show maximum benefit.

Q&A: Common Patient Questions

1. Who qualifies for Spravato treatment?
Spravato is typically prescribed to adults with treatment-resistant depression, meaning they have tried at least two other antidepressants without sufficient improvement.

2. How quickly does Spravato work compared to traditional antidepressants?
Spravato can sometimes lead to noticeable improvements within hours to days, whereas traditional antidepressants usually take weeks to take effect.

3. Is Spravato safe?
Yes, when administered in a certified clinic under medical supervision. Patients are monitored for at least two hours after each session due to possible side effects such as dizziness, dissociation, or increased blood pressure.

4. Do I still need therapy if I take Spravato?
Absolutely. Spravato addresses brain chemistry, but therapy and counseling address thought patterns, coping skills, and lifestyle changes—both are important for lasting recovery.

5. Will my insurance cover Spravato?
Many insurance plans do cover Spravato for eligible patients, but coverage varies. Phoenix Pointe Psychiatry’s team helps patients navigate the approval process.

10 Tips for Patients Considering Spravato or Traditional Antidepressants

1. Get a Comprehensive Evaluation – Ensure your diagnosis is accurate before starting any treatment.

2. Review Past Medication History – Your provider will consider what you’ve tried before and how you responded.

3. Ask About Side Effects – Understand potential risks for both Spravato and traditional antidepressants.

4. Set Realistic Expectations – Neither approach is a “magic cure,” and ongoing care is often needed.

5. Combine Medication with Therapy – Evidence shows outcomes improve when medications are paired with counseling.

6. Be Consistent with Treatment – Follow dosing schedules and attend all appointments.

7. Communicate with Your Provider – Report changes in mood, side effects, or concerns immediately.

8. Consider Lifestyle Factors – Diet, sleep, and exercise all play a role in recovery.

9. Involve Your Support System – Friends and family can provide encouragement and accountability.

10. Choose a Trusted Provider – Work with an experienced clinic that understands both advanced and traditional treatments.

Conclusion

Both Spravato and traditional antidepressants have an important place in the treatment of depression. The right choice depends on your medical history, current symptoms, and personal goals for recovery. For patients in Tempe and the surrounding Phoenix Metro area, Phoenix Pointe Psychiatry offers expert evaluation and treatment, including Spravato therapy, medication management, and personalized counseling.

If you or a loved one is struggling with depression, contact Phoenix Pointe Psychiatry in Tempe, Arizona today. We are committed to providing compassionate, evidence-based care to help you feel better—and stay better.